Tipo di tesi
Tesi di dottorato di ricerca
Titolo
CINETICHE DELLA VIREMIA DEL TORQUETENOVIRUS IN TRAPIANTATI DI ORGANO SOLIDO.
Settore scientifico disciplinare
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Corso di studi
FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO
Riassunto (Italiano)
Torquetenovirus (TTV) is a human anellovirus first discovered in 1997, and currently orphan from pathologies. We attempted to corroborate its use as a marker of functional immunosuppression in solid organ transplantation (SOT).
We selected two cohorts for different evaluations: kidney/pancreas transplant recipients for evaluation of induction immunosuppression, and orthotopic liver transplant recipients for evaluation of maintenance immunosuppression.
Our results confirm TTV as a T lymphocytotropic virus. TTV viremia serves as cheap surrogate of functional immune competence in SOT and kinetics is independent of allograft type. Short-term kinetics is driven by the type of induction immunosuppression, while long-term kinetics is driven by type and plasma level of maintenance immunosuppression.
TTV viremia is a good marker of iatrogenic immunosuppression and could be used to tailor-made maintenance immunosuppression.
