ETD

• DLBCL
• drug screening
• Germinal Center
• in-vitro assay
• Lymphoma
• Olfactory Receptor

Diffuse Large B-Cell Lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma. Although frontline immunochemotherapy achieves high cure rates, patients with relapsed or refractory disease still experience poor outcomes, highlighting the need for novel therapeutic strategies.

Olfactory receptors (ORs), a subgroup of G protein-coupled receptors, are ectopically expressed in several tissues and have recently been implicated in cancer-related processes. Emerging evidence suggests a potential involvement of selected ORs in the pathogenesis of DLBCL.

The aim of this work was to explore the preclinical activity of novel compounds targeting an olfactory receptor of interest in DLBCL models. Using in vitro approaches, the study investigated receptor-related effects on cellular responses, focusing on compound activity and specificity.

Overall, this thesis supports the relevance of olfactory receptors as promising molecular targets in DLBCL and provides a basis for further preclinical investigations toward innovative therapeutic approaches.