Tesi etd-12142025-144118 |
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Tipo di tesi
Tesi di dottorato di ricerca
Autore
FRANCONI, IACOPO
URN
etd-12142025-144118
Titolo
The genetic portrait of an emerging strain: from clinical fungal epidemiology of Aspergillus spp. and Candida spp to dissection of the drug resistance mechanisms of an azole resistant Candida parapsilosis
Settore scientifico disciplinare
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Corso di studi
SCIENZE CLINICHE E TRASLAZIONALI
Relatori
tutor Prof.ssa Lupetti, Antonella
Parole chiave
- azole resistance
- Candida parapsilosis
- fungal infections
Data inizio appello
18/12/2025
Consultabilità
Non consultabile
Data di rilascio
18/12/2028
Riassunto
Multiple reports from all over the world have described the emergence of non-albicans Candida species in the form of clinical outbreaks, caused mainly by Candida parapsilosis, Candida auris and Candida glabrata with an associated increase in drug resistance rates.
According to the WHO fungal priority list recommendations and in consideration of this evolving scenario, evaluation of local epidemiology of invasive fungal infections and associated antifungal susceptibility profiles is mandatory. Plus, authors from all over Italy are currently reporting several clinical outbreaks of azole resistant Candida parapsilosis and Candida auris especially in University Hospitals from north to south. Therefore, considering that the Azienda Ospedaliero-Universitaria Pisana is a tertiary level-care center of central Italy, studying the epidemiology of invasive fungal infections is of outmost importance.
Aim of this PhD thesis was to evaluate from a clinical to a genomic perspective, trends in invasive fungal infections and associated antifungal resistance profiles.
According to the WHO fungal priority list recommendations and in consideration of this evolving scenario, evaluation of local epidemiology of invasive fungal infections and associated antifungal susceptibility profiles is mandatory. Plus, authors from all over Italy are currently reporting several clinical outbreaks of azole resistant Candida parapsilosis and Candida auris especially in University Hospitals from north to south. Therefore, considering that the Azienda Ospedaliero-Universitaria Pisana is a tertiary level-care center of central Italy, studying the epidemiology of invasive fungal infections is of outmost importance.
Aim of this PhD thesis was to evaluate from a clinical to a genomic perspective, trends in invasive fungal infections and associated antifungal resistance profiles.
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