• atroposiomer
• isosorbide
• monophosphite
• phosphorus ligands
• renewable resources
• tropos

This thesis work explored the synthesis and the characterization of isosorbide derived biaryl monophosphite as well as their use as chiral metal ligands for asymmetric catalysis.
Firstly, the concept of double asymmetric induction and tropos activation is discussed by reporting various examples of atropoisomeric and tropos monophosphite ligands. In the second section, the synthesis of the flexible biaryl scaffolds as well as the optimization of the synthesis of biaryl derived monophosphate ligands is reported.
The structural characterization of the monophosphite ligands by means of 1D and 2D NMR spectroscopies and their stereochemical characterization by means of VT 31P-NMR, CD and temperature dependent-CD spectroscopies is also discussed.
Finally, because the monophosphite ligands were essayed as chiral ligands in Rh-catalyzed asymmetric addition of arylboronic acid to electronpoor alkenes and in Rh-catalyzed asymmetric hydrogenation of dimethylitaconate, in the last part of the thesis these results are discussed.