ETD

Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-11132020-001659


Tipo di tesi
Tesi di laurea magistrale LM6
Autore
TUBAK, THOMAS MATTEO
URN
etd-11132020-001659
Titolo
State Of The Art Of The Phage Therapy: A Systematic Review Of Case Reports Of The Last 20 Years
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
relatore Prof.ssa Freer, Giulia
relatore Prof.ssa Di Luca, Mariagrazia
Parole chiave
  • osteomyelitis
  • pji
  • uti
  • virus
  • toe
  • wound
  • burn
  • device
  • graft
  • cied
  • lvad
  • associated
  • amr
  • infection
  • pneumoniae
  • klebsiella
  • aeruginosa
  • pseudomonas
  • aureus
  • staphylococcus
  • fagoterapia
  • fagi
  • batteriofago
  • resistance
  • antibiotic
  • phage
  • phagetherapy
  • report
  • case
  • diabetic
  • clinical
  • review
  • systematic
  • therapy
  • bacteriophage
  • acinetobacter
  • baumannii
  • abscessus
  • mycobacterium
Data inizio appello
01/12/2020
Consultabilità
Non consultabile
Data di rilascio
01/12/2090
Riassunto
In the last years, the antibiotic resistance phenomenon has threatened healthcare systems all over the world and only a few newly developed antimicrobial drugs are reaching the pharma market. Among the potential alternative antibacterial treatment, phage therapy emerged as one of the most promising therapeutic options. The present thesis aims to evaluate phage therapy efficacy by performing a systematic review of the clinical case reported during the last twenty years. Data obtained by 38 selected articles were analyzed. Data related to bacterial species, type of infection, phage formulation administered with relative schedule, antibiotic drugs administered before and during the therapy, and outcomes were gathered. The result is promising, with 67% of the patients fully recovered and with bacterial eradication occurring in 90%. In most of the cases, the eradication was obtained when phages were added as an adjuvant to antibiotics, which were not able alone to cure infections. In comparison to clinical trials based on phage therapy reported in the literature, single case reports showed better outcomes. This is due to the viral nature of phages and their specificity and mechanism of action, suggesting that the rules for setting a trial based on phages should be different compared to synthesis molecules such as antibiotics.
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