• degradation
• piezoelectricity
• cytotoxicity
• potassium sodium niobate
• nanomaterials

This study investigates the chemical, physical, and biological properties of piezoelectric potassium sodium niobate nanoparticles (KNN nps). Additionally, it explores whether polymer coatings, specifically glycol chitosan, propylene glycol alginate, and polydopamine, can enhance both the dispersion of the nps and the concentration tested on cells compared to KNN nps alone. The chemical nature, composition, piezoelectric properties, and degradation behavior of KNN are examined, along with a characterization of KNN with the three different coatings. Biological properties, including viability, metabolic activity, and cytotoxicity on human chondrocyte cells, are also evaluated. The study aims to enhance our understanding of the properties and effects of KNN nps on chondrocytes by identifying the usage limits of particles in terms of the maximum usable concentration that is not cytotoxic. The goal is to advance the development of safe and degradable materials for medical applications.