Tipo di tesi
Tesi di specializzazione (4 anni)
Titolo
Psychomotor symptoms in major depressive episode are associated with bipolarity and treatment complexity: pooled analysis of the BRIDGE and BRIDGE-II-MIX cohorts.
Dipartimento
MEDICINA CLINICA E SPERIMENTALE
Corso di studi
PSICHIATRIA
Parole chiave
- bipolar depression
- major depressive episode
- psychomotor agitation
- psychomotor retardation
- psychomotor symptoms
Data inizio appello
11/12/2018
Consultabilità
Non consultabile
Data di rilascio
11/12/2088
Riassunto (Italiano)
The present pooled analysis investigated the role of psychomotor symptoms in depressed patients, evaluating the association with clinical characteristics of bipolar spectrum.
The whole sample (n=8496), obtained by pooling the two cohorts from the BRIDGE and the BRIDGE-II-Mix studies, was divided in 3 subgroups: the psychomotor retardation (PR), the psychomotor agitation (PA) and the non-psychomotor symptoms (NPS) groups. Sociodemographic and clinical variables were analyzed through Chi-square and ANOVA tests. Stepwise backward logistic regression models were used to identify clinical predictors of the subgroups.
In both PR and PA clinical variables related to bipolarity and a diagnosis of bipolar disorder were significantly more frequent than in the NPS group. PA was more related than PR with a “bipolar diathesis” in terms of comorbidity, variables associated with bipolarity, global impairment and diagnostic distribution of BD.
Psychomotor symptoms during depression have a discriminating validity and could be considered as a marker of bipolarity. PA and PR were associated with different clinical and course characteristics, underlining the importance of discriminating the motor patterns in MDE.
