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Tesi etd-11022022-232149


Tipo di tesi
Tesi di dottorato di ricerca
Autore
SANTALUCIA, DELIO
URN
etd-11022022-232149
Titolo
Study of new synthetic approaches to the production of isoprostanoic derivatives.
Settore scientifico disciplinare
CHIM/06
Corso di studi
SCIENZE CHIMICHE E DEI MATERIALI
Relatori
tutor Prof. Mandoli, Alessandro
tutor Prof. Di Francesco, Fabio
Parole chiave
  • isoprostanes
  • pentannulation.
  • stereoselective synthesis
  • total synthesis
Data inizio appello
07/11/2022
Consultabilità
Non consultabile
Data di rilascio
07/11/2025
Riassunto
Isoprostanes (IsoPs) arise from the radical peroxidation of polyunsaturated fatty acids and are stereoisomers of the well-known prostaglandins. Since their importance as suitable biomarkers for a large number of different pathologies is increasing, the research of synthetic strategy for their production attracted the interest of organic chemists. In this PhD Theis work new synthetic ways to produce a known intermediate for the production of IsoPs has been explored. A novel and concise sequence with high control of the relative configuration of the stereocentres is presented.
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