• adverse remodeling
• cardiology
• heart failure
• inflammation
• left ventricular remodeling
• no-reflow
• STEMI

ReModeling in ST-elevation myocARdial infarction: A comparison of left VEntricuLar functions in long-term follow-up among STEMI patients (The MARVEL study)
Background:
Primary percutaneous coronary intervention (PCI) is the reperfusion strategy of choice for patients presenting with ST-segment elevation myocardial infarction (STEMI). However, despite the restoration of epicardial flow (“recanalization”), primary PCI occasionally does not produce an effective reperfusion of myocardial tissue even in early and very early presenters (e.g., within 6 or 3 hours from symptom onset) leading to a relevant myocardial damage and the following adverse left ventricular remodeling (LVR).
The purpose of our study is to better investigate predictors and causal factors in developing LVR in patients with STEMI.
Methods:
This is a prospective cohort study that includes STEMI patients with age >18. Exclusion criteria are: severe valvular disease (already known), previous revascularization, previous MI, 3-vessel disease or LM going to surgery.
Enrolment and variable to collect:
Consecutive patients with the diagnosis of ST elevation myocardial infarction (STEMI) admitted at our institution will be enrolled. The following characteristics will be collected at admission and follow up: time to reperfusion (time from onset of pain to balloon), ventricular function/dysfunction and final infarct size. Diagnoses will be defined with echocardiography and MRI.