logo SBA

ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-10302023-200123


Tipo di tesi
Tesi di laurea magistrale LM6
Autore
RANIERI, MARGHERITA
URN
etd-10302023-200123
Titolo
ReModeling in ST-elevation myocARdial infarction: A comparison of left VEntricuLar functions in long-term follow-up among STEMI patients (The MARVEL study)
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
relatore Morrone, Doralisa
relatore De Caterina, Raffaele
Parole chiave
  • adverse remodeling
  • cardiology
  • heart failure
  • inflammation
  • left ventricular remodeling
  • no-reflow
  • STEMI
Data inizio appello
05/12/2023
Consultabilità
Non consultabile
Data di rilascio
05/12/2093
Riassunto
ReModeling in ST-elevation myocARdial infarction: A comparison of left VEntricuLar functions in long-term follow-up among STEMI patients (The MARVEL study)
Background:
Primary percutaneous coronary intervention (PCI) is the reperfusion strategy of choice for patients presenting with ST-segment elevation myocardial infarction (STEMI). However, despite the restoration of epicardial flow (“recanalization”), primary PCI occasionally does not produce an effective reperfusion of myocardial tissue even in early and very early presenters (e.g., within 6 or 3 hours from symptom onset) leading to a relevant myocardial damage and the following adverse left ventricular remodeling (LVR).
The purpose of our study is to better investigate predictors and causal factors in developing LVR in patients with STEMI.
Methods:
This is a prospective cohort study that includes STEMI patients with age >18. Exclusion criteria are: severe valvular disease (already known), previous revascularization, previous MI, 3-vessel disease or LM going to surgery.
Enrolment and variable to collect:
Consecutive patients with the diagnosis of ST elevation myocardial infarction (STEMI) admitted at our institution will be enrolled. The following characteristics will be collected at admission and follow up: time to reperfusion (time from onset of pain to balloon), ventricular function/dysfunction and final infarct size. Diagnoses will be defined with echocardiography and MRI.

File