Tesi etd-10272025-105553 |
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Tipo di tesi
Tesi di specializzazione (4 anni)
Autore
ZINI, LEONARDO
URN
etd-10272025-105553
Titolo
Immune microenvironment in sinonasal intestinal-type adenocarcinomas: clinical outcomes and correlations between prognosis and histopathology
Dipartimento
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Corso di studi
OTORINOLARINGOIATRIA
Relatori
relatore Dott. Dallan, Iacopo
Parole chiave
- adenocarcinoma
- immune
- itac
- microenvironment
- nasal
- prognosis
- til
Data inizio appello
18/11/2025
Consultabilità
Non consultabile
Data di rilascio
18/11/2095
Riassunto
Sinonasal intestinal-type adenocarcinoma is a rare disease, associated with work-related risk factors, burdened by diagnostic latency and high morbidity and mortality. In the later stages of the disease, therapeutic options are few. Recently, histopathological classification of this disease has undergone review and change in order to better understand its biology; in particular, immune microenvironment is a novel research field with possible diagnostic and therapeutic implications. In this multi-centric work we pooled together clinical data from Pisa and Brescia in order to better understand the histopathological characteristics and prognosis of the different kind of immune microenvironment in this rare disease.
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