Tesi etd-10252019-194714 |
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Tipo di tesi
Tesi di specializzazione (4 anni)
Autore
SCHIRRU, ALESSANDRO
URN
etd-10252019-194714
Titolo
The influence of CLOCK and Per2 genes in an Italian cohort of Alzheimer's Disease and Mild Cognitive Impairment patients: genetic and actigraphic data
Dipartimento
MEDICINA CLINICA E SPERIMENTALE
Corso di studi
NEUROLOGIA
Relatori
relatore Prof. Siciliano, Gabriele
correlatore Dott.ssa Bonanni, Enrica
correlatore Dott.ssa Bonanni, Enrica
Parole chiave
- actigrafo
- actigraphy
- Alzheimer disease
- circadian rhythms
- clock genes
- geni clock
- mild cognitive mpairment
- ritmi circadiani
- sleep
- sonno
Data inizio appello
14/11/2019
Consultabilità
Non consultabile
Data di rilascio
14/11/2089
Riassunto
The interest in chronobiology has raised in recent years, also thanks to the contribution of molecular biology in detecting the genes responsible for circadian rhythms, because the understanding of mechanisms underlying circadian rhythms and their changes in normal ageing and pathologies like neurodegeneration could provide new approaches in diagnosing and preventing these disorders.
The aims of the study were (1) to determinethe incidence of circadian locomotor output cycle kaput (CLOCK) gene T3111C and PER2 gene C111G polymorphisms in a cohort of Alzheimer’s disease and Mild Cognitive Impairment patients compared to healthy age matched controls, (2) to evaluate sleep parameters and circadian rhythms in the same population by actigraphy.
The aims of the study were (1) to determinethe incidence of circadian locomotor output cycle kaput (CLOCK) gene T3111C and PER2 gene C111G polymorphisms in a cohort of Alzheimer’s disease and Mild Cognitive Impairment patients compared to healthy age matched controls, (2) to evaluate sleep parameters and circadian rhythms in the same population by actigraphy.
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