Tesi etd-10232023-163924 |
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Tipo di tesi
Tesi di specializzazione (4 anni)
Autore
NONNE, GIOVANNA
URN
etd-10232023-163924
Titolo
Discriminating between Brain-first and Body-first Parkinson's Disease using radiomics-enhanced dopamine transporter SPECT image analysis and DaTQUANT semi-quantitative output data.
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA NUCLEARE
Relatori
relatore Prof. Volterrani, Duccio
correlatore Dott.ssa Aghakhanyan, Gayane
correlatore Dott.ssa Aghakhanyan, Gayane
Parole chiave
- 123-I-FP-CIT
- Parkinson's Disease
- radiomics
- Single-photon emission computed tomography
Data inizio appello
06/11/2023
Consultabilità
Non consultabile
Data di rilascio
06/11/2093
Riassunto
Recently it has been hypothesized that Parkinson’s Disease comprises two subtypes: a brain-first (top-down) type, where alpha-synuclein pathology initially arises in the brain with secondary spreading to the peripheral autonomic nervous system, and a body-first (bottom-up) type, where the pathology originates in the enteric or peripheral autonomic nervous system and then spreads to the brain. Our study aims to reveal possible differences between the two subtypes using radiomics-enhanced dopamine transporter SPECT image analysis and DaTQUANT semi-quantitative output data.
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