• artificial intelligence
• electrophysiology
• magnetic resonance imaging
• sudden cardiac death
• ventricular tachycardia

Radiofrequency catheter ablation is a safe and effective treatment for scar-related ventricular arrhythmias. Preliminary studies have shown that real time integration of late gadolinium enhancement magnetic resonance images (LGE-CMR) with electroanatomical mapping (EAM) systems can lead to improved procedural efficacy, efficiency and safety.
We present the preliminary results of a prespecified interim analysis of the VOYAGE trial, a prospective, randomized, multicenter controlled open label study aimed at comparing in terms of efficacy, efficiency and safety a CMR aided/guided approach to standard EAM-guided ventricular tachycardia (VT) ablation.
Patients with an ICD or with ICD implantation expected within 1 month with structural left ventricle heart disease and scar-related VT were randomized to a CMR-guided or a CMR-aided approach with LGE-CMR image post-processing performed with an artificial intelligence powered software (ADAS3D), while subjects unsuitable for imaging or with image quality deemed not sufficient for postprocessing were allocated to standard of care ablation.
Primary endpoint was defined as VT recurrence within 12-months follow up (either sustained or requiring ICD therapy), with a 1-month blanking period. Secondary endpoints included procedural efficiency, safety and impact on quality of life.