Tesi etd-10052021-103919 |
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Tipo di tesi
Tesi di laurea magistrale
Autore
CRISTIANI, SOFIA
URN
etd-10052021-103919
Titolo
Oxidative and glycative stress effects on human lens epithelial cells
Dipartimento
BIOLOGIA
Corso di studi
BIOLOGIA MOLECOLARE E CELLULARE
Relatori
relatore Dott.ssa Moschini, Roberta
Parole chiave
- aldose reductase
- carbonyl reductase
- polyol pathway
- inflammation
- NF-κB
- lipid peroxidation
- oxidative stress
Data inizio appello
26/10/2021
Consultabilità
Non consultabile
Data di rilascio
26/10/2091
Riassunto
This thesis is focused on providing evidence that human lens epithelial cells (HLECs) can respond to two natural pro-inflammatory stimuli, 4-hydroxy-2-nonenal (HNE) and D-glucose, leading to the activation of the inflammatory response pathway associated with transcription factor NF-κB and cyclooxygenase-2 (COX-2), in order to recapitulate some typical diabetes complications and to test the effectiveness of inhibitors of aldose reductase and carbonyl reductase, whose enzymatic activity is highly connected with inflammation.
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