ETD

Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-09102021-112439


Tipo di tesi
Tesi di laurea magistrale
Autore
SAVIOZZI, CHIARA
URN
etd-09102021-112439
Titolo
Design, synthesis and characterization of new trinuclear iron complexes with potential antitumor activity.
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Prof. Marchetti, Fabio
Parole chiave
  • metal-based drugs
  • redox
  • ferrocene
  • chemistry
  • inorganic
  • organometallic
  • anticancer
  • antitumour
  • antitumor
  • vinyliminium
  • cyanide
  • aminocarbyne
  • bridging
  • dinuclear
  • trinuclear
  • iron
  • biological
Data inizio appello
21/10/2021
Consultabilità
Non consultabile
Data di rilascio
21/10/2091
Riassunto
The objectives of the present work can be summarized as follows:
1) Synthesis of a new triiron aminocarbyne compound with formula [Fe2Cp2(CO)2(μ-CO){μ-CNMe(Fc)}]CF3SO3 starting from [Fe2Cp2(CO)4], via substitution of a carbonyl ligand with isocyanoferrocene (CNFc) followed by alkylation of the coordinated isocyanide.
2) Synthesis of derivatives obtained by (i) mono- and di-substitution of terminal carbonyls with selected ligands; (ii) functionalization of the aminocarbyne ligand by alkyne insertion, affording ferrocenyl-vinyliminium complexes.
3) Characterization by analytical and spectroscopic methods. Assessment of the stability of selected compounds in both water and cell culture media, with a view to the biological applications. Planning of electrochemical studies and preliminary cytotoxicity investigations in collaborations with other research groups.
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