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Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-08312021-153125


Tipo di tesi
Tesi di laurea magistrale LM5
Autore
POMPILI, LIVIA
URN
etd-08312021-153125
Titolo
Sintesi di Inibitori Reversibili della Monoacilglicerolo lipasi (MAGL) a Struttura Benzilpiperidinica e Benzilpiperazinica
Dipartimento
FARMACIA
Corso di studi
CHIMICA E TECNOLOGIA FARMACEUTICHE
Relatori
relatore Prof. Minutolo, Filippo
relatore Prof.ssa Granchi, Carlotta
Parole chiave
  • cancer
  • cancer cells
  • cancro
  • ECS
  • endocannabinoids
  • MAGL
  • MAGL inhibitors
  • monoacilglicerolo lipasi
  • monoacylglycerol lipase
  • sistema endocannabinoide
Data inizio appello
04/10/2021
Consultabilità
Non consultabile
Data di rilascio
04/10/2024
Riassunto
Monoacylglycerol lipase (MAGL) is a serine hydrolase enzyme which converts 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor agonist, into fatty acids and glycerol. MAGL inactivation leads to increased 2-AG levels in the CNS and, as a consequence, to reductions in arachidonic acid (AA) and derivatives, producing antinociceptive, anxiolytic and antineuroinflammatory effects. During my work I tried to synthesize two types of MAGL inhibitors, both reversible. The first series of compounds presents a benzylpyperidinic structure and comes from a series of benzoylpyperidinic compounds synthesized by my professors' group. The second series of compounds derives from the irreversible MAGL inhibitor ABX-1431, on which I made structural changes in order to obtain a reversible inhibitor.
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