Tipo di tesi
Tesi di laurea magistrale LM5
Titolo
Sintesi di Inibitori Reversibili della Monoacilglicerolo lipasi (MAGL) a Struttura Benzilpiperidinica e Benzilpiperazinica
Corso di studi
CHIMICA E TECNOLOGIA FARMACEUTICHE
Parole chiave
- cancer
- cancer cells
- cancro
- ECS
- endocannabinoids
- MAGL
- MAGL inhibitors
- monoacilglicerolo lipasi
- monoacylglycerol lipase
- sistema endocannabinoide
Data inizio appello
04/10/2021
Consultabilità
Non consultabile
Data di rilascio
04/10/2091
Riassunto (Italiano)
Monoacylglycerol lipase (MAGL) is a serine hydrolase enzyme which converts 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor agonist, into fatty acids and glycerol. MAGL inactivation leads to increased 2-AG levels in the CNS and, as a consequence, to reductions in arachidonic acid (AA) and derivatives, producing antinociceptive, anxiolytic and antineuroinflammatory effects. During my work I tried to synthesize two types of MAGL inhibitors, both reversible. The first series of compounds presents a benzylpyperidinic structure and comes from a series of benzoylpyperidinic compounds synthesized by my professors' group. The second series of compounds derives from the irreversible MAGL inhibitor ABX-1431, on which I made structural changes in order to obtain a reversible inhibitor.
