• MAGL
• monoacilglicerolo lipasi
• ECS
• endocannabinoids
• cancer
• cancro
• cancer cells
• MAGL inhibitors
• sistema endocannabinoide
• monoacylglycerol lipase

Monoacylglycerol lipase (MAGL) is a serine hydrolase enzyme which converts 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor agonist, into fatty acids and glycerol. MAGL inactivation leads to increased 2-AG levels in the CNS and, as a consequence, to reductions in arachidonic acid (AA) and derivatives, producing antinociceptive, anxiolytic and antineuroinflammatory effects. During my work I tried to synthesize two types of MAGL inhibitors, both reversible. The first series of compounds presents a benzylpyperidinic structure and comes from a series of benzoylpyperidinic compounds synthesized by my professors' group. The second series of compounds derives from the irreversible MAGL inhibitor ABX-1431, on which I made structural changes in order to obtain a reversible inhibitor.