Tesi etd-08262024-130823 |
Link copiato negli appunti
Tipo di tesi
Tesi di laurea magistrale LM6
Autore
MANGONI, BEATRICE
URN
etd-08262024-130823
Titolo
Clinical correlates of Cognitive Impairment in elderly patients with Bipolar Spectrum Disorders
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
relatore Prof. Perugi, Giulio
Parole chiave
- Bipolar Spectrum Disorders
- Cognitive Impairment
- correlates
- elderly
Data inizio appello
24/09/2024
Consultabilità
Non consultabile
Data di rilascio
24/09/2094
Riassunto
Abstract
Background: Increased risk of mild cognitive impairment (MCI) and dementia has been observed in Older Age Bipolar Disorder (OABD). However, the factors driving this association are not yet well studied. Considering that this population represents more than 25% of all patients with bipolar disorder (BD), the shortage of information in this area deserves to be addressed.
Aim of the study: The aim of this study is to outline the clinical features associated with the development of MCI and/or dementia in elderly patients (over 50 years old) with bipolar spectrum disorder.
Materials and Methods: 152 patients aged 50 years or older and diagnosed with bipolar spectrum disorders based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria were included in the study and were subdivided into two subgroups based on the presence/absence of cognitive impairment. Subsequently, a subdivision into three subgroups according to the absence of cognitive impairment and the presence of MCI or dementia was made. Univariate comparisons were performed to assess the associations between clinical variables and cognitive impairment.
Results: Cognitively impaired patients with BD had a higher prevalence of otherwise- specified BD than BD type 2 compared to cognitively unimpaired patients. Moreover, a later onset of the first affective episode of any polarity and a higher prevalence of dyslipidemia and vascular leukoencephalopathy were observed in cognitively impaired versus cognitively unimpaired participants. Current symptom severity and functional impairments measured by Clinical Global Impression (CGI), Global Assessment of Functioning (GAF) and Brief Psychiatric Rating Scale (BPRS) scores were more severe in patients with cognitive impairment, with an increasing trend from MCI to dementia.
Conclusion: This study suggests that atypical features, late onset and metabolic comorbidity may predict the development of MCI and dementia in patients with
2
OABD. As expected, the severity of symptoms is more pronounced in patients with comorbid cognitive impairment and BD.
Background: Increased risk of mild cognitive impairment (MCI) and dementia has been observed in Older Age Bipolar Disorder (OABD). However, the factors driving this association are not yet well studied. Considering that this population represents more than 25% of all patients with bipolar disorder (BD), the shortage of information in this area deserves to be addressed.
Aim of the study: The aim of this study is to outline the clinical features associated with the development of MCI and/or dementia in elderly patients (over 50 years old) with bipolar spectrum disorder.
Materials and Methods: 152 patients aged 50 years or older and diagnosed with bipolar spectrum disorders based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria were included in the study and were subdivided into two subgroups based on the presence/absence of cognitive impairment. Subsequently, a subdivision into three subgroups according to the absence of cognitive impairment and the presence of MCI or dementia was made. Univariate comparisons were performed to assess the associations between clinical variables and cognitive impairment.
Results: Cognitively impaired patients with BD had a higher prevalence of otherwise- specified BD than BD type 2 compared to cognitively unimpaired patients. Moreover, a later onset of the first affective episode of any polarity and a higher prevalence of dyslipidemia and vascular leukoencephalopathy were observed in cognitively impaired versus cognitively unimpaired participants. Current symptom severity and functional impairments measured by Clinical Global Impression (CGI), Global Assessment of Functioning (GAF) and Brief Psychiatric Rating Scale (BPRS) scores were more severe in patients with cognitive impairment, with an increasing trend from MCI to dementia.
Conclusion: This study suggests that atypical features, late onset and metabolic comorbidity may predict the development of MCI and dementia in patients with
2
OABD. As expected, the severity of symptoms is more pronounced in patients with comorbid cognitive impairment and BD.
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