• engram
• proteomics
• synapse
• memory

Memories define who we are. The accumulation of our memories builds a story from which we are able to learn, connect experiences and even make a general sense of our lives. The singular importance of this phenomenon is most evident in cases in which we have a disruption, such as is often seen in Alzheimer’s disease, resulting in a progressive and significant deterioration of an individual’s daily well-being (Denny, Lebois and Ramirez, 2017). It is therefore self-evident that understanding memory has been the central aim of a multitude of intellectuals spanning centuries of philosophical argumentation and scientific studies. In the past century, understanding the formation, maintenance and retrieval of memories has been a dominant endeavor of neuroscientific research (Tonegawa et al., 2015). Increasing evidence supports the notion that protein alterations occur at the level of synapses following memory formation (for review Poo, Pignatelli and Ryan, 2016). This thesis aims to illustrate recent work conducted towards elucidating the changes that occur among interacting proteins at the post synaptic density as a means to work towards gathering an understanding of the physical substrate that entails a memory (Fernández et al., 2009).