Tesi etd-07062018-192635 |
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Tipo di tesi
Tesi di laurea magistrale
Autore
SCHOCH, SILVIA
URN
etd-07062018-192635
Titolo
Synthesis and characterisation of organometallic diiron complexes with potential anticancer activity.
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Prof. Marchetti, Fabio
Parole chiave
- metal-based drugs
- iron
- bridging
- aminocarbyne
- cyanide
- antitumour
- antitumor
- anticancer
- organometallic
- chemistry
- inorganic
- nucleophilic addition
- MTT assay
- biological
- binding studies
Data inizio appello
25/07/2018
Consultabilità
Non consultabile
Data di rilascio
25/07/2088
Riassunto
The main objectives of this thesis can be summarised as follows:
1. Synthesis and characterisation of new diiron vinyliminium complexes with variable substituents and of some related derivatives;
2. Evaluation of the in vitro antiproliferative activity of the complexes towards A2780, A2780R and HEK293 cell lines;
3. Study of the interaction of diiron vinyliminium complexes with biomolecules, with the aim of giving insight to their possible mechanism of action.
1. Synthesis and characterisation of new diiron vinyliminium complexes with variable substituents and of some related derivatives;
2. Evaluation of the in vitro antiproliferative activity of the complexes towards A2780, A2780R and HEK293 cell lines;
3. Study of the interaction of diiron vinyliminium complexes with biomolecules, with the aim of giving insight to their possible mechanism of action.
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