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Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-07062018-192635


Tipo di tesi
Tesi di laurea magistrale
Autore
SCHOCH, SILVIA
URN
etd-07062018-192635
Titolo
Synthesis and characterisation of organometallic diiron complexes with potential anticancer activity.
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Prof. Marchetti, Fabio
Parole chiave
  • aminocarbyne
  • anticancer
  • antitumor
  • antitumour
  • binding studies
  • biological
  • bridging
  • chemistry
  • cyanide
  • inorganic
  • iron
  • metal-based drugs
  • MTT assay
  • nucleophilic addition
  • organometallic
Data inizio appello
25/07/2018
Consultabilità
Non consultabile
Data di rilascio
25/07/2088
Riassunto
The main objectives of this thesis can be summarised as follows:
1. Synthesis and characterisation of new diiron vinyliminium complexes with variable substituents and of some related derivatives;
2. Evaluation of the in vitro antiproliferative activity of the complexes towards A2780, A2780R and HEK293 cell lines;
3. Study of the interaction of diiron vinyliminium complexes with biomolecules, with the aim of giving insight to their possible mechanism of action.
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