Tesi etd-06242026-181044 |
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Tipo di tesi
Tesi di laurea magistrale LM6
URN
etd-06242026-181044
Titolo
Multimodal and Multidisciplinary Assessment of Dysphagia in Amyotrophic Lateral Sclerosis: a Clinical Experience with an Integrated Approach
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
.
relatore Prof. Ceravolo, Roberto
Parole chiave
- DYALS
- dysphagia
- multidisciplinary
Data inizio appello
14/07/2026
Consultabilità
Non consultabile
Data di rilascio
14/07/2096
Riassunto (Inglese)
Amyotrophic Lateral Sclerosis is a fatal neurodegenerative disease in which dysphagia represents a critical challenge.
A cohort of ALS patients was longitudinally evaluated. Dysphagia was assessed both subjectively, using the DYALS questionnaire, and objectively through FEES, including a standardized pooling score (PS) assessed with a solid-dry bolus. Based on this score, participants were classified as dysphagic (PS >= 6) or non-dysphagic.
Patients showed a heterogeneous but progressive disease course, with a variable rate of decline. Nonetheless, DYALS scores increased over time, reflecting worsening subjective dysphagia, in parallel with an increase in the number of objectively dysphagic patients.
Furthermore, at baseline, a discrepancy emerged between objective and subjective measures. DYALS scores showed a higher trend in the dysphagic group, although this was not statistically significant (p=0.21). The lack of significance may reflect the incomplete agreement between patient-reported symptoms and objective swallowing assessments.
These findings confirm the clinical heterogeneity of ALS, highlighting the importance of combining standardized questionnaires with objective assessments to better characterize individual disease trajectories and optimize multidisciplinary care.
A cohort of ALS patients was longitudinally evaluated. Dysphagia was assessed both subjectively, using the DYALS questionnaire, and objectively through FEES, including a standardized pooling score (PS) assessed with a solid-dry bolus. Based on this score, participants were classified as dysphagic (PS >= 6) or non-dysphagic.
Patients showed a heterogeneous but progressive disease course, with a variable rate of decline. Nonetheless, DYALS scores increased over time, reflecting worsening subjective dysphagia, in parallel with an increase in the number of objectively dysphagic patients.
Furthermore, at baseline, a discrepancy emerged between objective and subjective measures. DYALS scores showed a higher trend in the dysphagic group, although this was not statistically significant (p=0.21). The lack of significance may reflect the incomplete agreement between patient-reported symptoms and objective swallowing assessments.
These findings confirm the clinical heterogeneity of ALS, highlighting the importance of combining standardized questionnaires with objective assessments to better characterize individual disease trajectories and optimize multidisciplinary care.
Riassunto (Italiano)
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