ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-06142023-180338

Tipo di tesi

Tesi di laurea magistrale

URN

etd-06142023-180338

Titolo

Multiscale reaction-diffusion in-silico model to design and predict hydrogels viscoelastic properties for the study of cell mechanotransduction

Dipartimento

INGEGNERIA DELL'INFORMAZIONE

Corso di studi

INGEGNERIA BIOMEDICA

Parole chiave

hydrogel in-silico models
mechanotransduction
predict hydrogel viscoelastic properties

Data inizio appello

25/07/2023

Consultabilità

Non consultabile

Data di rilascio

25/07/2093

Riassunto (Inglese)

Riassunto (Italiano)

The aim of the thesis was to develop an computational model for describing and predicting hydrogels viscoelastic properties in order to study cell mechanotransduction. Reaction-diffusion and mechanical models were optimized with experimental data performed on Agarose-Hyaluronic Acid hydrogels. The proof of concept was to identify the adequate concentration conditions of the hydrogel materials, to analyse how Adipose-derived stem cell (ADSCs) differently response to various substrate conformations.

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