logo SBA

ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-06142021-104127


Tipo di tesi
Tesi di laurea magistrale LM5
Autore
CAFA', ELIANA
URN
etd-06142021-104127
Titolo
Sintesi di nuovi analoghi della Tizoxanide con potenziale attivita antivirale
Dipartimento
FARMACIA
Corso di studi
CHIMICA E TECNOLOGIA FARMACEUTICHE
Relatori
relatore Prof. Minutolo, Filippo
relatore Prof.ssa Granchi, Carlotta
Parole chiave
  • antiviral drug
  • COVID-19
  • N-hydroxyindole derivatives
  • Nitazoxanide
Data inizio appello
07/07/2021
Consultabilità
Non consultabile
Data di rilascio
07/07/2061
Riassunto
Synthesis of molecules with potential antiviral activity with N-hydroxindolic structure, bioisosterically similar to Nitazoxanide, an antiparasitic drug used in the treatment of COVID-19 for pharmacological repositioning. Nitazoxanide is an in vivo deacetylated prodrug to the active metabolite, Tizoxanide. The proposed mechanism of action for Tizoxanide and, consequently, for the newly synthesized derivatives, targets the human enzyme ERp57, also known as PDIA3, a thiol-disulfide oxidoreductase which constitutes a fundamental step for the activation of the viral F protein, responsible for the fusion of the virus to host cells.
File