Tipo di tesi
Tesi di dottorato di ricerca
Titolo
Design and sustainable synthesis of new green materials for biomedical applications
Settore scientifico disciplinare
CHEM-05/A - Chimica organica
Corso di studi
SCIENZE CHIMICHE E DEI MATERIALI
Riassunto (Italiano)
The new challenges of modern biomedicine require a molecular approach to rationalize and enhance the properties of new materials for surgical applications or the discovery of new drugs for pharmacological use. A deeper understanding of the relationship between molecular structures and physicochemical properties is crucial. Therefore, two different research lines were pursued. The first one aimed to develop mimetics of natural peptides based on (S)-indoline-2-carboxylic acid ((2S)-Ind), focusing on the comprehension of (2S)-Ind reactivity with both α- and β-amino acids and the influence of (2S)-Ind on conformational properties of (2S)-Ind-containing hetero-sequences. The second part focused on a structure-property study for developing HA-based materials for aesthetic medicine application, using mono- and polydisperse poly(ethylene glycol) diglycidyl ethers (PEGDEs) as cross-linkers, aiming to highlight the effect of the PEGDE chain length on the HA-based hydrogel properties.
