logo SBA

ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-05202025-190932


Tipo di tesi
Tesi di dottorato di ricerca
Autore
CORDELLA, FABIANA
URN
etd-05202025-190932
Titolo
Design and sustainable synthesis of new green materials for biomedical applications
Settore scientifico disciplinare
CHEM-05/A - Chimica organica
Corso di studi
SCIENZE CHIMICHE E DEI MATERIALI
Relatori
tutor Prof. Angelici, Gaetano
relatore Prof.ssa Martinelli, Elisa
Parole chiave
  • (S)-indoline-2-carboxylic acid
  • biomedical application
  • conformational properties
  • cross-linking degree
  • hyaluronic acid
  • PEGDE
  • peptide mimetics
  • reactivity
  • rheology
Data inizio appello
30/05/2025
Consultabilità
Non consultabile
Data di rilascio
30/05/2095
Riassunto
The new challenges of modern biomedicine require a molecular approach to rationalize and enhance the properties of new materials for surgical applications or the discovery of new drugs for pharmacological use. A deeper understanding of the relationship between molecular structures and physicochemical properties is crucial. Therefore, two different research lines were pursued. The first one aimed to develop mimetics of natural peptides based on (S)-indoline-2-carboxylic acid ((2S)-Ind), focusing on the comprehension of (2S)-Ind reactivity with both α- and β-amino acids and the influence of (2S)-Ind on conformational properties of (2S)-Ind-containing hetero-sequences. The second part focused on a structure-property study for developing HA-based materials for aesthetic medicine application, using mono- and polydisperse poly(ethylene glycol) diglycidyl ethers (PEGDEs) as cross-linkers, aiming to highlight the effect of the PEGDE chain length on the HA-based hydrogel properties.
File