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Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-05192022-112516


Tipo di tesi
Tesi di laurea magistrale LM6
Autore
PARDOSSI, SIMONE
URN
etd-05192022-112516
Titolo
Correlation between skin cancer and therapy with anti-IL monoclonal antibodies in patients affected by moderate to severe psoriasis
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
relatore Prof. Romanelli, Marco
correlatore Prof.ssa Dini, Valentina
correlatore Dott. Panduri, Salvatore
Parole chiave
  • biologics
  • IL-17
  • IL-23
  • monoclonal antibodies
  • psoriasis
  • skin cancer
Data inizio appello
14/06/2022
Consultabilità
Completa
Riassunto
Moderate to severe psoriasis tends to be treated with biological drugs. In recent years, the most widely used monoclonal antibodies are those targeting IL-17 and IL-23 patterns. Although registration studies of these drugs have shown excellent safety, there are still no prospective studies on the correlation between their use and skin cancer. Therefore, this cross-sectional study takes into account 127 patients referred to the psoriasis outpatient clinic of the UO Dermatology Pisa, looking for the presence of cancer or precancerous lesions in individuals taking monoclonal antibodies against IL-17 or anti IL-23.
The characteristics of our population were studied, from comorbidities to concomitant therapies that could have an impact on tumour occurrence. We found cancer occurrence in 12 individuals, with cancer onset averaging 22 months. Finally, we characterised the cancers, studying a possible correlation with the individuals' variables.
This study therefore lays the foundations for a possible future multicentre prospective study.
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