Tesi etd-05172016-112408 |
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Tipo di tesi
Tesi di laurea specialistica LC5
Autore
WAIZMAN, MILLY
URN
etd-05172016-112408
Titolo
Pharmacological properties, therapeutic efficacy and safety of use of ustekinumab in immune-mediated inflammatory diseases
Dipartimento
FARMACIA
Corso di studi
FARMACIA
Relatori
relatore Prof. Blandizzi, Corrado
Parole chiave
- IL-12
- IL-23
- IMID
- ustekinumab
Data inizio appello
08/06/2016
Consultabilità
Non consultabile
Data di rilascio
08/06/2086
Riassunto
Ustekinumab is a fully human monoclonal antibody, generated via molecular engineering from transgenic mice, genetically modified so they cannot produce murine antibodies, but only human antibodies. Ustekinumab binds in a selective manner to the p40 subunit which contributes to the structure of both IL-12 (p35/p40) and IL-23 (p19/p40), which play a key role in the pathogenesis of immune-mediated inflammatory diseases (IMIDs).
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