Tesi etd-05132007-140145 |
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Tipo di tesi
Tesi di dottorato di ricerca
Autore
Danti, Serena
URN
etd-05132007-140145
Titolo
Middle ear reconstruction using human mesenchymal stem cells and biological/biocompatible materials: a Tissue Engineering approach
Settore scientifico disciplinare
ING-IND/34
Corso di studi
TECNOLOGIE PER LA SALUTE: VALUTAZIONE E GESTIONE DELLE INNOVAZIONI NEL SETTORE BIOMEDICALE
Relatori
Relatore Prof. Mikos, Antonios G.
Relatore Prof. Berrettini, Stefano
Relatore Prof. Berrettini, Stefano
Parole chiave
- ear
- mastoid filling
- mesenchymal stem cells
- ossicular chain
Data inizio appello
14/03/2007
Consultabilità
Non consultabile
Data di rilascio
14/03/2047
Riassunto
The aim of this study was to find biological/biocompatible-based materials to be used with human
mesenchymal stem cells (hMSCs) as promising alternatives for bone replacements in the middle ear to
minimize the current autograft demand as mastoid fillers, as well as the prosthetic failures mainly due
to extrusion of implanted devices. For this purpose, forefront Tissue Engineering (TE) strategies have
been applied, such as the employment of hMSCs as a cellular source, the use of bioreactors for the in
vitro culture of the constructs, and the production of bone extracellular matrix (ECM)/synthetic
biomaterial composites to enhance the hMSCs osteogenesis and promote the device biocompatibility.
Many biological and biocompatible materials have been investigated as scaffolds for hMSCs, focusing
on the middle ear reconstruction. This study has shown that a TE approach in the middle ear
reconstruction is feasible and can give some interesting early outcomes for the patients.
mesenchymal stem cells (hMSCs) as promising alternatives for bone replacements in the middle ear to
minimize the current autograft demand as mastoid fillers, as well as the prosthetic failures mainly due
to extrusion of implanted devices. For this purpose, forefront Tissue Engineering (TE) strategies have
been applied, such as the employment of hMSCs as a cellular source, the use of bioreactors for the in
vitro culture of the constructs, and the production of bone extracellular matrix (ECM)/synthetic
biomaterial composites to enhance the hMSCs osteogenesis and promote the device biocompatibility.
Many biological and biocompatible materials have been investigated as scaffolds for hMSCs, focusing
on the middle ear reconstruction. This study has shown that a TE approach in the middle ear
reconstruction is feasible and can give some interesting early outcomes for the patients.
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