• Cyclosporine A
• Gingival hyperplasia
• Heart transpant patients
• Metronidazole gel

The cyclosporine-induced gingival overgrowth(go) is a widely documented side effect. Among the methods used to trat this clinical manifestation, the non surgical periodontal treatment associated with plaque control provided controversial results. Interesting results have been obtained using metronidazole systemically; this drug, however, interferes with the CSA metabolism, thus contra-indicating the simultaneous administration of the two molecules. At present, metronidazole is also available as mucoadhesive gel, wich allows to reach appropriate local concentrations without systemic side effects. Aim of this study is to evaluate the efficacy of locally-delivered metronidazole used in association with the therapy of go in heart transplant patients.