Tipo di tesi
Tesi di laurea magistrale
Titolo
Feasibility studies to the development of gallium(III)-glycoconjugates for the targeted anticancer chemotherapy.
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Riassunto (Italiano)
"Cancer" is used to define a group of diseases that may affect any part of the body.
These diseases are caused by the transformation of normal cells into tumor cells in a multi-stage process. A unique aspect of cancer is the rapid abnormal production and proliferation of cells. These cells will eventually spread to other organs and invade contiguous parts of the body. This phenomenon is also called metastasis and is the main cause of cancer death.
For the design of anti-cancer drugs, targeting tumors without affecting healthy tissues is challenging. For that reason, recent research has shifted from general cytotoxic therapeutics to rationally designed anticancer drugs that target over-expressed biomarkers or receptors in cancer cells.
To produce the energy needed for cellular processes, healthy differentiated cells primarily exploit mitochondrial oxidative phosphorylation.
