Tesi etd-04242023-221112 |
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Tipo di tesi
Tesi di laurea magistrale LM6
Autore
LANDI, MATTEO
URN
etd-04242023-221112
Titolo
Transcriptomic Signatures of MSI-high Metastatic ColoRectal Cancer and Efficacy of Immune Checkpoint Inhibitors
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Relatori
relatore Prof.ssa Cremolini, Chiara
relatore Dott.ssa Antoniotti, Carlotta
relatore Dott.ssa Antoniotti, Carlotta
Parole chiave
- colorectal cancer
- immune checkpoint inhibitors
- immunotherapy
- microsatellite instability
- pembrolizumab
Data inizio appello
23/05/2023
Consultabilità
Non consultabile
Data di rilascio
23/05/2026
Riassunto
The present work tries to answer the question of if there exist biomarkers predictive of sensitivity or resistance to immune checkpoint inhibitors in metastatic colorectal cancer. We performed transcriptomic analyses on a cohort of 110 Italian patients and applied two literature-published signatures before comparing RNAseq results with clinical data. We identified a transcriptional profile that is expressed more significantly in patients with short progression-free survivals. These data prove the starting hypothesis but will need further validation to confirm the potential of transcriptomic analysis as a predictive biomarker of response/resistance to ICIs in mCRC.
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