Tesi etd-03202025-131632 |
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Tipo di tesi
Tesi di laurea magistrale
Autore
PISANI, NICOLE
URN
etd-03202025-131632
Titolo
Studio delle alterazioni molecolari di linee cellulari di adenocarcinoma duttale pancreatico (PDAC) trattate con FOLFIRINOX
Dipartimento
BIOLOGIA
Corso di studi
BIOLOGIA APPLICATA ALLA BIOMEDICINA
Relatori
relatore Prof. Signore, Giovanni
relatore Dott.ssa Mosca, Rossella
relatore Dott.ssa Mosca, Rossella
Parole chiave
- cancer cells
- CAT
- DAPI
- FOLFIRINOX
- GSR
- GST
- MitoSOX
- Nile RED
- PDAC
Data inizio appello
07/04/2025
Consultabilità
Non consultabile
Data di rilascio
07/04/2095
Riassunto
The experimental study aims to study the metabolic and molecular changes in different pancreatic ductal adenocarcinoma (PDAC) cell lines treated with the combined chemotherapy FOLFIRINOX. The overall objective is to outline a detailed map of the cellular responses implemented by pancreatic tumor cells during chemotherapy treatments, identifying not only the molecular defense mechanisms, but also the timing with which these mechanisms are activated and consolidated over time. The results obtained may contribute to identifying new potential therapeutic targets and to developing targeted strategies to overcome chemoresistance, thus improving the efficacy of the therapies currently available for patients affected by pancreatic ductal adenocarcinoma.
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