Tipo di tesi
Tesi di dottorato di ricerca
Titolo
Purpose Tailoring of Bioactive-Biocompatible Polymers as Soluble Drug Carriers
and Hydrogels for Drug Delivery Systems
Settore scientifico disciplinare
CHIM/05 - SCIENZA E TECNOLOGIA DEI MATERIALI POLIMERICI
Corso di studi
BIOMATERIALI
Riassunto (Italiano)
During the PhD course I have studied poly(amido amine)s based nanostructured systems, that can be considered as part of the huge field of the polymer therapeutics.
After a brief intrpduction about polymer therapeutics and a general review concerning poly(amidoamines), the work done during the PhD course is reported, divided in the following main chapters: Kinetic study of PAAs synthesis in organic solvents; Synthesis of new polymeric precursors of PAA-drug or PAA-protein conjugate by disulfide bond; Synthesis of nano-structured PAA-Cholesterol conjugates; Syntesys of cross linked polyplexes for applications in gene delivery; Glass surface functionalization for AFM imaging of lipid systems.
