Tesi etd-02272010-151301 |
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Tipo di tesi
Tesi di dottorato di ricerca
Autore
BUDA, GABRIELE
URN
etd-02272010-151301
Titolo
Role of single nucleotide polymorphisms in multiple myeloma
Settore scientifico disciplinare
BIO/18
Corso di studi
MICROBIOLOGIA E GENETICA
Relatori
tutor Prof. Petrini, Mario
Parole chiave
- MDR
- chemotherapy
- multiple myeloma
Data inizio appello
22/03/2010
Consultabilità
Non consultabile
Data di rilascio
22/03/2050
Riassunto
Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to drug response variability. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy for the individual patient30. In a pharmacogenetic prospective, the present study examined the correlation between the outcome of MM patients (in terms of therapy response and survival) after VAD induction therapy and PBSCT and the presence of genetic polymorphisms in genes involved in xenobiotic metabolism (GSTP1 and NQO1), folate transport (SLC19A1), DNA synthesis (TYMS) and multidrug resistance (MDR1). Furthermore we evaluated the role of MDR1 in relapsed multiple myeloma treated with bortezomib
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