ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-02262013-191122

Tipo di tesi

Tesi di dottorato di ricerca

URN

etd-02262013-191122

Titolo

The endocannabinoid system: 1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. 2. Study of the ischemic damage effects in cannabinoid receptors knockout mice.

Settore scientifico disciplinare

CHIM/08 - CHIMICA FARMACEUTICA

Corso di studi

FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO

Parole chiave

cannabinoid
ischemic disease
MAGL inhibitor

Data inizio appello

27/03/2013

Consultabilità

Completa

Riassunto (Inglese)

Riassunto (Italiano)

My PhD thesis is about the study of different aspect of endocannabinoid system. In particular during my reserach project I focused my attention on two different topics:
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...
2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.

File

Nome file	Dimensione
PhD_thes...telli.pdf	3.60 Mb
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