Tesi etd-02262013-191122 |
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Tipo di tesi
Tesi di dottorato di ricerca
Autore
CASTELLI, FRANCESCA
URN
etd-02262013-191122
Titolo
The endocannabinoid system:
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors.
2. Study of the ischemic damage effects in cannabinoid receptors knockout mice.
Settore scientifico disciplinare
CHIM/08
Corso di studi
FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO
Relatori
tutor Prof.ssa Manera, Clementina
Parole chiave
- cannabinoid
- ischemic disease
- MAGL inhibitor
Data inizio appello
27/03/2013
Consultabilità
Completa
Riassunto
My PhD thesis is about the study of different aspect of endocannabinoid system. In particular during my reserach project I focused my attention on two different topics:
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...
2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...
2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.
File
| Nome file | Dimensione |
|---|---|
| PhD_thes...telli.pdf | 3.60 Mb |
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