Tipo di tesi
Tesi di laurea magistrale
Titolo
Modelling of the functional amyloid aggregation at the synapse.
New insights into the local computational properties of neurons.
Corso di studi
BIOLOGIA APPLICATA ALLA BIOMEDICINA
Parole chiave
- amyloids
- CPEB
- molecular memory
- Orb2
- physiological amyloids
- protein aggregation
- synaptic rule
Data inizio appello
29/02/2016
Riassunto (Italiano)
The regulation of mRNA translation at synaptic level is believed to be fundamental in memory and learning at cellular level. A family of RNA binding proteins (RBPs) which emerged to be important during development and in adult neurons is the one of Cytoplasmic Polyadenylation
Element Binding proteins (CPEBs). Drosophila Orb2 (homolog of vertebrate CPEB2 protein and of the neural isoform of Aplysia CPEB) has been found to be involved in the translation of plasticity-dependent mRNAs and has been associated to Long Term Memory (LTM). Orb2 protein presents two
main isoforms, Orb2A and Orb2B, which form an activity induced amyloid-like functional aggregate, which is thought to be the translation-inducing state of the RBP. I present a two-states continuous differential model for Orb2A-Orb2B aggregation and I propose it, more generally, as a new
synaptic facilitation rule for learning processes involving protein aggregation-dependent plasticity (PADP).
