ETD

Archivio digitale delle tesi discusse presso l’Università di Pisa

Tesi etd-01232018-105345

Tipo di tesi

Tesi di laurea magistrale

URN

etd-01232018-105345

Titolo

Synthesis and characterization of organo-iron complexes with potential anticancer activity

Dipartimento

CHIMICA E CHIMICA INDUSTRIALE

Corso di studi

CHIMICA

Parole chiave

anticancer
iron
metal-based drugs
optimization
synthesis
vinyliminium

Data inizio appello

08/02/2018

Consultabilità

Completa

Riassunto (Inglese)

Riassunto (Italiano)

The main objectives of the present work of thesis are the following:
1. Optimization of the synthesis of diiron vinyliminium complexes, taking into account their air and water stability;
2. Synthesis of new diiron vinyliminium complexes with variable substituents, to tune electronic and steric factors with the aim of evaluating the effects of these variations on the anticancer activity;
3. Synthesis of new monoiron vinyl-aminocarbene complexes using an optimized procedure, and preliminary evaluation of their cytotoxicity.

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