Tesi etd-01112026-173622 |
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Tipo di tesi
Tesi di specializzazione (5 anni)
Autore
BONATO, ADELE
URN
etd-01112026-173622
Titolo
Association between intestinal Geotrichum candidum and long-term benefit to immune checkpoint blockade despite antibiotics consumption
Dipartimento
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
ONCOLOGIA MEDICA
Relatori
relatore Cremolini, Chiara
Parole chiave
- Antibiotics
- Fungi
- Gut dysbiosis
- Gut microbiota
- Immunotherapy
Data inizio appello
27/01/2026
Consultabilità
Non consultabile
Data di rilascio
27/01/2029
Riassunto
Antibiotics (ATBs) impair the efficacy of immune checkpoint inhibitors (ICIs) in solid tumors. In this prospective study, we show that ATB spectrum reshapes gut bacterial, archaeal, and fungal communities and alters host immunometabolism. Interestingly, ATB-associated enrichment of Geotrichum candidum was linked to improved outcomes and counteracted the negative effect of ATBs on progression-free and overall survival in ICI-treated patients. The causative link between gut residence of Geotrichum candidum and restoration of ICI responsiveness during antibiotic-induced dysbiosis was further demonstrated in murine models.
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