Thesis etd-01082022-172154 |
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Thesis type
Tesi di laurea magistrale
Author
BALDASSARI, CARLO
URN
etd-01082022-172154
Thesis title
Amino-derivatives of isohexides as chiral building blocks for the synthesis of CSA for NMR spectroscopy
Department
CHIMICA E CHIMICA INDUSTRIALE
Course of study
CHIMICA
Supervisors
relatore Prof.ssa Iuliano, Anna
Keywords
- amides
- aminoalcohol
- chiral solvating agents
- diamine
- isohexide
- NMR spectroscopy
- regioselective synthesis
- stereospecific synthesis
- thioureas
- ureas
Graduation session start date
28/01/2022
Availability
Withheld
Release date
28/01/2025
Summary
Synthesis and characterization of diamine and aminoalcohol derivatives from isohexides, through stereospecific and regioselective reactions. These new chiral building blocks have been used for the development of regioselective and stereospecific protocols for the preparation of new arylureas, arylthioureas and arylamides with different stereochemistry and functionalization. These new chiral auxiliaries have been employed as chiral solvating agents for NMR spectroscopic enantiodiscrimination of derivatized aminoacids, to study the influence of different parameters such as stereochemistry and/or derivatization of the scaffold on their chiral recognition capability.
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