Tesi etd-01082022-172154 |
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Tipo di tesi
Tesi di laurea magistrale
Autore
BALDASSARI, CARLO
URN
etd-01082022-172154
Titolo
Amino-derivatives of isohexides as chiral building blocks for the synthesis of CSA for NMR spectroscopy
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Prof.ssa Iuliano, Anna
Parole chiave
- ureas
- amides
- diamine
- aminoalcohol
- isohexide
- thioureas
- NMR spectroscopy
- chiral solvating agents
- stereospecific synthesis
- regioselective synthesis
Data inizio appello
28/01/2022
Consultabilità
Non consultabile
Data di rilascio
28/01/2025
Riassunto
Synthesis and characterization of diamine and aminoalcohol derivatives from isohexides, through stereospecific and regioselective reactions. These new chiral building blocks have been used for the development of regioselective and stereospecific protocols for the preparation of new arylureas, arylthioureas and arylamides with different stereochemistry and functionalization. These new chiral auxiliaries have been employed as chiral solvating agents for NMR spectroscopic enantiodiscrimination of derivatized aminoacids, to study the influence of different parameters such as stereochemistry and/or derivatization of the scaffold on their chiral recognition capability.
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