ETD system

Electronic theses and dissertations repository

 

Tesi etd-10032017-101803


Thesis type
Tesi di laurea magistrale
Author
FIOCO, DAVID
URN
etd-10032017-101803
Title
Synthesis, characterization and properties of platinum(IV) complexes bearing triphenylphosphine
Struttura
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Commissione
relatore Samaritani, Simona
Parole chiave
  • acetonitrile
  • iodobenzene dichloride
  • ammine
  • platinum
  • complexes
  • triphenylphosphine
  • Oxidation
  • chlorine
  • bromine
Data inizio appello
19/10/2017;
Consultabilità
parziale
Data di rilascio
19/10/2020
Riassunto analitico
Taking into account the good results collected in previous years for platinum(II) complexes containing PPh3 ligand, the main goals of this thesis can be summarized as follows:
1) Finding a synthetic pathway for the synthesis of triphenylphosphine bearing Platinum (IV) complexes. With Platinum easily undergoing reduction and triphenylphosphine being extremely easy to oxidize and capable of reacting even with the smallest traces of water found in a solvent this is no trivial issue.
2) Studying the reactivity of the Platinum (IV) complexes obtained and their overall stability over time. It is generally assumed that Platinum (IV) complexes are more inert to ligand substitution but there is no data on Platinum (IV) complexes bearing triphenylphosphine being tested for such reaction.
3) With the aim of testing bromine or its synthetic equivalents as oxidizing reagents, synthesis of brominated platinum (II) complexes bearing triphenylphosphine. The preparation of suitable precursors when using bromine as an oxidant is necessary to minimize the possibility of halogen exchange reactions. Anyway, the availability of brominated analogs of chlorinated cytotoxic systems will allow the comparison of biological properties. While there have been documented uses of iodine bearing complexes in anticancer treatments there is little data available on bromine bearing species. In particular, there is no data at all regarding the combination of bromine and triphenylphosphine.
4) Preliminary analysis of oxidation reactions on Platinum (II) complexes bearing bromine.
File