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Tesi etd-06262019-123558


Thesis type
Tesi di laurea magistrale
Author
ANTONUCCIO, MARIA NICOLE
URN
etd-06262019-123558
Title
Towards the translation of patient-specific simulations into clinics: an integrated approach in guiding CFD analysis for a non-invasive study of aortic coarctation
Struttura
INGEGNERIA DELL'INFORMAZIONE
Corso di studi
INGEGNERIA BIOMEDICA
Commissione
relatore Prof.ssa Celi, Simona
tutor Ing. Sauvage, Emilie
tutor Ing. Fanni, Benigno Marco
correlatore Prof. Mariotti, Alessandro
controrelatore Prof. Positano, Vincenzo
Parole chiave
  • Windkessel model
  • aortic coarctation
  • CFD simulations
  • numerical models
  • sensitivity analysis
  • uncertainty quantification
Data inizio appello
12/07/2019;
Consultabilità
secretata d'ufficio
Data di rilascio
12/07/2022
Riassunto analitico
In this work, the hemodynamics of a patient afflicted by aortic coarctation was investigated, integrating Computational Fluid-Dynamics simulations and Magnetic Resonance Imaging data. Starting from MR images, acquired as part of the clinical routine, it was possible to reconstruct the 3D geometry of the patient, both in pre and post-intervention cases. The patient-specific flow conditions were prescribed at the ascending aorta as the inlet boundary condition; 3-elements Windkessel models were the outlet boundary conditions. A sensitivity analysis of these parameters was carried out in a deterministic and stochastic way, with a final quantification of the uncertainty of an input parameter on the output of the simulations.
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