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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-12202021-213047


Thesis type
Tesi di specializzazione (4 anni)
Author
ROGANI, SARA
URN
etd-12202021-213047
Thesis title
"CORRELATION BETWEEN FRAILTY, BPSD AND CORTICAL ATROPHY IN OLDER PATIENTS DIAGNOSED WITH DEMENTIA: A SINGLE CENTER LONGITUDINAL STUDY"
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
GERIATRIA
Supervisors
relatore Prof. Monzani, Fabio
correlatore Dott.ssa Calsolaro, Valeria
Keywords
  • dementia
  • Alzheimer
  • BPSD
  • frailty
  • brain atrophy
Graduation session start date
07/01/2022
Availability
Withheld
Release date
07/01/2092
Summary
Dementia is a clinical syndrome characterized by progressive cognitive decline and loss of independence in activities of daily living. Alongside the cognitive symptoms, Behavioral and Psychological Symptoms of Dementia (BPSD) may arise, causing considerable distress to both patients and caregivers. The primary objective of my study was to evaluate the possible correlation between frailty and BPSD in elderly patients with dementia referred to our Memory Clinic. Secondary objective was to evaluate the possible correlation between BPSD and neurodegeneration in terms of brain atrophy, assessed with PA and GCA scale. The NPI scale was used in order to assess the presence and severity of BPSD. According to literature, BPSD were classified in three different clusters: “mood/apathy” (depression, apathy, sleep disturbances, appetite disturbances), ”psychosis” (delusions, hallucinations and anxiety) and “hyperactivity” (agitation, elation, motor aberrant behavior, irritability, disinhibition). The results of my study showed a significant correlation between frailty and “hyperactivity” cluster, both at baseline and follow up visits. I also detected a significant correlation between the number of symptoms of “hyperactivity” cluster and posterior cortical atrophy as measured with PA scale. A similar trend, although not statistically significant, was found for the GCA scale. These data suggest the usefulness of an in-depth study in a larger cohort of patients with cognitive impairment and BPSD.
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