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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-12172021-140951


Thesis type
Tesi di specializzazione (4 anni)
Author
ABEL, JOEL REUBEN
URN
etd-12172021-140951
Thesis title
Assessment of the incidence and differente types of laryngotracheal sequelae in COVID-19 patients subjected to prolonged invasive ventilation
Department
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Course of study
OTORINOLARINGOIATRIA
Supervisors
relatore Prof. Berrettini, Stefano
relatore Dott. Fiacchini, Giacomo
Keywords
  • dysphonia
  • dysphagia
  • prolonged invasive ventilation
  • laryngotracheal sequelae
  • covid19
Graduation session start date
11/01/2022
Availability
Withheld
Release date
11/01/2092
Summary
The new Coronavirus Disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, may require admission to an Intensive Care Unit (ICU) for massive interstitial pneumonia for up to 12% of all patients who contract the infection, with possible orotracheal intubation and subsequent tracheostomy to allow adequate invasive mechanical ventilation. The most common airway-related complications of such ICU maneuvers are laryngotracheal granulomas, scar webs, stenosis, tracheomalacia and, less commonly, tracheal necrosis with tracheo-esophageal or tracheo-arterial fistulas.
According to the current literature, it is clear today that patients subjected to prolonged intubation for COVID-19 interstitial pneumonia may have an higher incidence of tracheal complications during hospitalization or in the early post-treatment period than a control population. These patients may also have an higher incidence of long-term laryngotracheal sequelae. In fact, it is already well known in the literature that patients undergoing prolonged intubation (> 8 days) have an higher risk of developing both acute and late laryngotracheal complications. For these reasons, the main objective of this study is to evaluate the incidence and the different patterns of laryngotracheal sequelae in a COVID-19 group of patients subjected to prolonged invasive ventilation and to compare these aspects with non-COVID-19 matched controls. Secondly, we administered two specific questionnaires to assess dysphonia and dysphagia in both groups.
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