logo SBA

ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-12082021-160907


Thesis type
Tesi di specializzazione (4 anni)
Author
DE DOMINICIS, FRANCESCO
URN
etd-12082021-160907
Thesis title
Pharmacological treatment of Emotional Dysregulation in adults with ADHD: a longitudinal observational study
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
PSICHIATRIA
Supervisors
relatore Prof. Perugi, Giulio
relatore Dott.ssa Schiavi, Elisa
Keywords
  • atomoxetine
  • methylphenidate
  • stimulants
  • emotional dysregulation
  • adult adhd
Graduation session start date
29/12/2021
Availability
Withheld
Release date
29/12/2091
Summary
The Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder mostly diagnosed in childhood but also recognized in adulthood with a major clinical, diagnostic and therapeutic complexity. In addition to the classic nuclear symptoms of inattentiveness, hyperactivity and impulsivity, it is important the role assumed by Emotional Dysregulation (ED) that should be considered a nuclear symptom, a diagnostic criterion and a target for pharmacological treatment. We enrolled 80 adult patients diagnosed with ADHD (26 with inattentive manifestation, 1 with hyperactive/impulsive manifestation, 53 with combined manifestation) from first prescription of specific drugs for this condition (Methylphenidate, Atomoxetine). We excluded patients with concomitant intellectual disability and those who already were receiving specific treatment for more than 14 days. At baseline, we assessed the clinical ADHD severity, using Conners’ Adult ADHD Rating Scales–Observer: Short Version (CAARS–O:S), and ED-related aspects, using the Reactivity, Intensity, Polarity and Stability questionnaire (RIPoSt), and we observed them for a mean of 20 weeks (sd 4.75). We detected an improvement in ED symptoms with no significant difference between assumption of Methylphenidate or Atomoxetine. This response has been significant only in combined manifestation. Our findings support the importance of ED in adult ADHD and its targeted treatment.
File