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Tesi etd-12072019-110626


Thesis type
Tesi di dottorato di ricerca
Author
BERTELLI, ELENA
URN
etd-12072019-110626
Title
The era of translational medicine: from circulating tumor cells to radiomics and deep learning.
Settore scientifico disciplinare
MED/36
Corso di studi
SCIENZE CLINICHE E TRASLAZIONALI
Supervisors
tutor Prof. Caramella, Davide
correlatore Prof. Serni, Sergio
Parole chiave
  • Prostate cancer
  • Texture analysis
  • Circulating tumor cells
  • Lung cancer
  • Radiomics
Data inizio appello
16/12/2019;
Consultabilità
Parziale
Data di rilascio
16/12/2022
Riassunto analitico
My PhD project araises from the major change that medicine and healthcare are experiencing in the last decades, moving from reactive to proactive approaches by providing Predictive, Preventive and Personalised medical solutions for the individual patients.
The aim of this PhD project was to explore the role of radiomics and radiogenomics in lung and prostate cancers. At first I focused on the possible contribution of detecting circulating tumor cells and microemboli to diagnostic work up of patients with suspected malignant pulmonary lesions. At the same time we investigate the potential role of quantitative shape analysis in allowing CT differentiation between benign and malignant pulmonary nodules. In this perspective of translational medicine I started to collaborate with some engineers for the evaluation of the potential applications of Radiomics in the oncological field. Prostate cancer is extremely fit for this purpose, so we evaluate the role of radiomics features in predicting prostate cancer aggressiveness.
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