ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-12012020-122303


Thesis type
Tesi di specializzazione (3 anni)
Author
BORTOLI, ELEONORA
URN
etd-12012020-122303
Thesis title
PRODUCTION AND DOSIMETRIC CHARACTERIZATION OF A FLASH ELECTRON BEAM
Department
FISICA
Course of study
FISICA MEDICA
Supervisors
relatore Dott. Di Martino, Fabio
Keywords
  • FLASH
  • electron beam
  • dosimetry
  • high dose-per-pulse
  • dose rate
  • IORT
Graduation session start date
16/12/2020
Availability
None
Summary
Recently, a new promising delivery method, called FLASH radiotherapy, combines technological development and novel radiobiology by delivering ionizing radiation therapy at high dose rates (at least 40 Gy/s), much higher than the ones used in conventional radiotherapy (CONV-RT), which is usually 0.03 Gy/s. The aim of this work is to transform a pre-existing Inta-Operative-Radiotherapy (IORT) machine for electron FLASH-RT experiments, obtaining a device able to operate in an ultra high dose rate regime with a reproducible and simple methodology, providing reliable performance. The experimental measurements in order to verify relative and absolute dosimetric characterization demonstrated that the proposed design allows reaching a FLASH dose rate, which can be suitable both for dosimetric tests and for radiobiological studies on cells and small animals.
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