ETD

Digital archive of theses discussed at the University of Pisa

Thesis etd-11222008-201743

Thesis type

Tesi di dottorato di ricerca

URN

etd-11222008-201743

Thesis title

Randomized Comparison of Sirolimus and Paclitaxel Drug-Eluting Stents for Long Lesions in the Left Anterior Descending Artery: an Intravascular Ultrasound Study

Academic discipline

MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE

Course of study

FISIOPATOLOGIA E CLINICA DELL'APPARATO CARDIOVASCOLARE E RESPIRATORIO

Keywords

comparison
drug eluting stent
IVUS
PCI

Graduation session start date

06/12/2008

Availability

Full

Abstract (Inglese)

Abstract (Italiano)

The objective of this prospective randomized study was to verify whether the superiority of the sirolimus-eluting stent (SES) in inhibiting neointimal hyperplasia could be demonstrated in complex coronary lesions. The SES was compared with the paclitaxel-eluting stent (PES) in long lesions of the left anterior descending artery with intravascular ultrasound (IVUS) and quantitative angiography. Late luminal loss and mean neointimal hyperplasia were significantly lower in the SES group compared to the PES group and peri-stent plaque area was significantly reduced in the SES group only. Both groups had excellent IVUS and angiographic results at 9-month follow up.

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