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ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-11222008-201743


Thesis type
Tesi di dottorato di ricerca
Author
BRANCHITTA, GIULIA
URN
etd-11222008-201743
Thesis title
Randomized Comparison of Sirolimus and Paclitaxel Drug-Eluting Stents for Long Lesions in the Left Anterior Descending Artery: an Intravascular Ultrasound Study
Academic discipline
MED/11
Course of study
FISIOPATOLOGIA E CLINICA DELL'APPARATO CARDIOVASCOLARE E RESPIRATORIO
Supervisors
Relatore Prof.ssa Petronio, Anna Sonia
Keywords
  • comparison
  • drug eluting stent
  • IVUS
  • PCI
Graduation session start date
06/12/2008
Availability
Full
Summary
The objective of this prospective randomized study was to verify whether the superiority of the sirolimus-eluting stent (SES) in inhibiting neointimal hyperplasia could be demonstrated in complex coronary lesions. The SES was compared with the paclitaxel-eluting stent (PES) in long lesions of the left anterior descending artery with intravascular ultrasound (IVUS) and quantitative angiography. Late luminal loss and mean neointimal hyperplasia were significantly lower in the SES group compared to the PES group and peri-stent plaque area was significantly reduced in the SES group only. Both groups had excellent IVUS and angiographic results at 9-month follow up.
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