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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-11152015-090537


Thesis type
Tesi di laurea magistrale LM5
Author
ARCABASSO, GIAN MARCO
URN
etd-11152015-090537
Thesis title
The application of scaffolds in tissue engineering: 42 cases of an in vivo experimental study on bone regeneration in critical bone defects.
Department
SCIENZE VETERINARIE
Course of study
MEDICINA VETERINARIA
Supervisors
relatore Prof. Carlucci, Fabio
correlatore Dott. Melanie, Pierre
controrelatore Prof. Citi, Simonetta
Keywords
  • tissue engineering
  • surgical treatment
  • scaffolds
  • critical bone defects
  • bone regeneration
  • traumatic pathologies
Graduation session start date
11/12/2015
Availability
Full
Summary
Surgical treatment of major traumatic pathologies, in which there are critical-size bone defects, includes transplantation of tissue from one site to another in the same patient ( autograft) or from one individual to another ( transplant or allograft). Problems exist with all these techniques.
The field of tissue engineering and regenerative medicine aims to regenerate damaged tissues, instead of replacing them, by developing biological substitutes, by restoring, by maintaining or improving tissue function.
As our first mundial review on PCL scaffolds in bone tissue, we have reported an experience in repairing that has confirmed its biocompatibility. No signs of local or systemic toxicity were detected in the site of implant and no foreign body reaction was found. Histological examination of samples confirmed the absence of necrosis, inflammation or fibrosis areas.
The radiological and histological evidence of newly formed bone tissue penetrating into the scaffold structure validates its osteoconductivity and osteoinductivity, confirming the possibility to use scaffolds as an alternative to standard bone grafts for the treatment of bone critical size defects.
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