• glioblastoma
• immunohistochemistry
• mismatch repair proteins
• molecular characterization
• recurrency
• Tissue MicroArray

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite the combination of novel therapeutical approaches to the standard treatment, GBM is still a deadly malignancy with extremely poor prognosis.
Microsatellite instability (MSI) is one of the most investigated molecular mechanisms and has been related to better prognosis and treatment response in other solid tumors. Mutations in genes associated with DNA mismatch repair (MMR), result in a MSI phenotype and promote tumor initiation and growth. Nevertheless, MMR deficiency may induces neoantigen production promoting durable immune surveillance.
Nowadays, the role of MMR status in GBMs is controversial. The present project try to address this issue, and lay the foundation for further investigations able to elucidate the still uncharted complex interactions between GBM cancer cells, tumor immune microenvironment and host response.