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ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-11142006-175044


Thesis type
Tesi di dottorato di ricerca
Author
Pietra, Daniele
email address
daniele2674@yahoo.it
URN
etd-11142006-175044
Thesis title
Binding sites on G-protein Coupled Receptors. Implications in Design of Bivalent Ligands and Allosteric modulation
Academic discipline
BIO/14
Course of study
FISIOPATOLOGIA MEDICA E FARMACOLOGIA
Supervisors
Relatore Dott.ssa Bianucci, Anna Maria
Relatore Prof.ssa Breschi, Maria Cristina
Keywords
  • allosteric modulation
  • bivalent ligands
  • G-protein coupled receptors
Graduation session start date
18/12/2006
Availability
Full
Summary
This thesis is aimed at providing an overview about the relevant role played in drug design by the knowledge, at a molecular level, of ligand (drug)-receptor (biological terget) interactions as well as paths that ligands should follow to reach their binding site(s) within the receptor. This research led at developing a basic approach for rational design of ligands, which are endowed of particular mechanisms, that is bivalent ligands and allosteric modulators, of interaction with the receptor of interest.
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