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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-11082018-215014


Thesis type
Tesi di specializzazione (4 anni)
Author
MAINARDI, CECILIA
URN
etd-11082018-215014
Thesis title
Psychomotor symptoms in major depressive episode are associated with bipolarity and treatment complexity: pooled analysis of the BRIDGE and BRIDGE-II-MIX cohorts.
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
PSICHIATRIA
Supervisors
relatore Prof. Perugi, Giulio
Keywords
  • psychomotor symptoms
  • psychomotor retardation
  • psychomotor agitation
  • bipolar depression
  • major depressive episode
Graduation session start date
11/12/2018
Availability
Withheld
Release date
11/12/2088
Summary
The present pooled analysis investigated the role of psychomotor symptoms in depressed patients, evaluating the association with clinical characteristics of bipolar spectrum.
The whole sample (n=8496), obtained by pooling the two cohorts from the BRIDGE and the BRIDGE-II-Mix studies, was divided in 3 subgroups: the psychomotor retardation (PR), the psychomotor agitation (PA) and the non-psychomotor symptoms (NPS) groups. Sociodemographic and clinical variables were analyzed through Chi-square and ANOVA tests. Stepwise backward logistic regression models were used to identify clinical predictors of the subgroups.
In both PR and PA clinical variables related to bipolarity and a diagnosis of bipolar disorder were significantly more frequent than in the NPS group. PA was more related than PR with a “bipolar diathesis” in terms of comorbidity, variables associated with bipolarity, global impairment and diagnostic distribution of BD.
Psychomotor symptoms during depression have a discriminating validity and could be considered as a marker of bipolarity. PA and PR were associated with different clinical and course characteristics, underlining the importance of discriminating the motor patterns in MDE.
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